An adaptive immune reaction is completed immediately after antigen recognition by adaptive immune cells (B cells and T cells) after extended-term antigen recognition and memory.
variety II cells proliferate and differentiate into variety I cells, As a result actively reforming the alveolar epithelium following damage and advertising alveolar repair service (71). kind II cells Convey CD74 on their own floor. through acute injury for instance viral an infection, style I cells launch MIF. Extracellular MIF binds to CD74 on adjacent form II epithelial cells, activating Akt and ERK pathways, leading to cell proliferation and differentiation to restore the alveolar barrier (seventy two).
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The receptor that mediated MIF action remained elusive till a examine in 2003, which used a cDNA library and fluorescently conjugated MIF to monitor for just a receptor and determined CD74 as being the MIF receptor. The authors explained that MIF sure to the extracellular domain of CD74, resulting in extracellular sign-controlled kinase (ERK) pathway activation (25).
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